We present the first case report of evolvement of Diabetes
Insipidus in a patient, 18 years after the established diagnosis of
Sheehan’s syndrome. Our patient also has documented occurrence of
Mollaret’s syndrome 12 years prior to the recent development of
Diabetes Insipidus.
Diabetes Insipidus has been reported as a rare complication of
Sheehan’s syndrome. Our case report is unique, as the symptoms and
the diagnosis of Diabetes Insipidus occurred about 18 years after
the onset of Sheehan’s Syndrome.
An important fact which ws observed in our patient was the
corticosteroids aggravated the underlying Diabetes Insipidus. As the
patient was non-compliant with the steroid replacement in the past
and was more compliant now, might explain the delayed appearance of
the symptoms of Diabetes Insipidus.
Interestingly, Herpes Simplex virus has been linked with Mollaret’s
syndrome as well as with development of Diabetes Insipidus. It is
possible that Herpes Simplex virus was the etiologic agent of
Mollaret’s syndrome and Diabetes Insipidus in this patient.
Our case report emphasized that we should be aware of Diabetes
Insipidus as a rare but established complication of Sheehans’
syndrome and that corticosteroids can worsen an existing Diabetes
Insipidus. Last but not the least, our case report speculates the
possibility of an association between Mollaret’s syndrome and
Diabetes Insipidus.