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 Missouri Resident Poster Competition 1999 Jamal Makhoul M.D.
Washington University To test our hypothesis that estrogen deficiency plays a role in
modifying dementia expression in elderly women, we compared the
severity of dementia ascertained by the Short Blessed Test (SBT) and
the Clinical Dementia Rating Scale (CDR) in two groups of women with
surgical Vs natural menopause. The surgical menopause group (SM) had a current age of 79.64±6.4
yr. and mean menopausal age of 44.67±5.11 yr. (n=28) and the
natural menopause group (NM) had a current age of 80.41±6.41 and
mean menopause age of 50.50±5.05 (n=64). The two groups did not
differ with respect to education (SM, 10.7yr. Vs NM, 10.7yr.). Comparison of Dementia Severity: Measure SM NM P CDR 1.77±0.84 1.12±0.58 0.000 SBT 19.82±7.17 14.13±8.44 0.001 The results indicate that despite comparable ages and education,
women with a SM had more severe or advanced dementia than women with
a NM and suggest that estrogen deficiency associated with a
hysterectomy may modify the expression of Alzheimer’s disease. |
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