Objective: to detect factors that might affect vascular compliance in young healthy subjects, and to detect whether family history of cardiovascular disease affects vascular compliance at young age.

Results: 143 subjects ages 18-33 were enrolled, small artery elasticity was significantly reduced in females (P<0.0001), with increased age (P= 0.0011), lower BMI (P=0.0003), and a higher heart rate (P<0.0001), large artery elasticity was significantly reduced in females (P=0.004), and with lower BMI (P=0.015). There was no significant difference in vascular compliance in relation to family history of cardiovascular disease, but there was a trend towards decreased small artery elasticity in subjects with parental history of hyperlipidemia (P=0.062).